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A different sort of route of introduction introduced the smallpox vaccine from Mexico to New Mexico (March 1805) and Tx (April 1806) which at that moment where part of the Viceroyalty of New Spain. The vaccine had been delivered to California in 1817 by Russian merchants who obtained it in Peru, where vaccine had appeared in 1806 aided by the Spanish Philanthropic Expedition for the Vaccine. It took nearly 150 several years of vaccination attempts prior to the last natural out
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