https://www.selleckchem.com/pr....oducts/epacadostat-i
Histidine is much more effective than aspartate in coordinating Zn2+ in the S3-S4 linker. A simple Hodgkin Huxley model of NpHV 1 suggests a decrease of the opening rate if it is inhibited by zinc or cadmium. Limiting slope measurements and high resolution clear native gel electrophoresis (hrCNE) confirmed that NpHV 1 functions as a dimer. The data supports the hypothesis that zinc is coordinated in between the dimer instead of the monomer. Zinc coordination sites may be potential targets for drug development. This articl
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