https://www.selleckchem.com/pr....oducts/pd-1-pd-l1-in
Unfolding and refolding of multidomain proteins under force have yet to be recognized as a major mechanism of function for proteins in vivo. In this review, we discuss the inherent properties of multidomain proteins under a force vector from a structural and functional perspective. We then characterize three main systems where multidomain proteins could play major roles through mechanical unfolding muscular contraction, cellular mechanotransduction, and bacterial adhesion. We analyze how key multidomain proteins for each
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