https://www.selleckchem.com/pr....oducts/epacadostat-i
85 ± 19.51µg/mL). Further, the flow-cytometric analysis revealed the increase in sub G1 population as well as early apoptotic populations dose-dependently. The results from confocal microscopy showed the DNA fragmentation in MCF-7 upon DCME treatment. Finally, the western blotting study revealed the induction of tumor suppressor protein, p53 which results in increasing Bax/Bcl-2 ratio and activation of caspase-cascade pathways. CONCLUSION The activation of caspase-3, -8, -9 and PARP degradation led us to conclude that DCM
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