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anatomy and physiology is taken into account. Moreover, the image quality enhancement leads to more plausible motion fields estimated by deformable image registration (DIR) in the 4D CBCT image sequences. The presented framework enables significantly boosting of 4D CBCT image quality as well as improved DIR and motion field consistency. Thus, the proposed method facilitates extraction of motion information from severely artifact-affected images, which is one of the key challenges of integrating 4D CBCT imaging into RT workflows. The pre
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