https://www.selleckchem.com/pr....oducts/sri-011381.ht
Diabetic nephropathy (dNP), now the leading cause of ESKD, lacks efficient therapies. Coagulation protease-dependent signaling modulates dNP, in part the G protein-coupled, protease-activated receptors (PARs). Specifically, the cytoprotective protease-activated protein C (aPC) protects from dNP, but the mechanisms are not clear. A combination of approaches and mouse models evaluated the role of aPC-integrin interaction and related signaling in dNP. The zymogen protein C and aPC bind to podocyte integrin- , a subunit of integrin- . De
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