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The cell-cell communications and substance flow stimulation separately, synergistically or contradictorily impacted the behavior of tongue SCC. Fluid flow stimulation synergistically enhanced the antiproliferative effectation of cis-diamminedichloroplatinum on tongue SCC cells, but mesenchymal cells abolished the synergistic antiproliferative result linked to substance circulation stimulation. In summary, a reconstructed model had been established to investigate the mobile and act
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