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CSO-ss-SA/siRNA could successfully transmit siRNA into tumor cells, decreasing the phrase of RAC1 protein by 38.2% and lowering the amount of tumor-induced intrusion cells by 42.5per cent. Whenever along with DOX, CSO-ss-SA/siRNA extremely inhibited the chemotherapy-induced EMT in vivo and enhanced therapeutic efficiency. The current research indicates that RAC1 protein is a key regulator of chemotherapy-induced EMT and CSO-ss-SA/siRNA silencing RAC1 could efficiently reduce ste
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