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The highest percentage of explained variance by the reference equation was obtained for FEF /FVC, 32%-38% for males, and 41%-46% for females, depending on the validation set. We developed reference equations for FVC-adjusted FEF values. We demonstrated minimally yet significantly improved variability. Future studies in obstructive airway diseases should demonstrate whether it is worthwhile to use these (predicted) adjusted FEF values. We developed reference equations for FVC-adjusted FEF values. We demonstrated minimally yet significantly
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