https://others-signal.com/opio....id-induced-constipat
Nevertheless, pharmacological reagents that inhibit IPMK haven't however already been identified. We employed a structure-based digital assessment of openly offered U.S. Food and Drug Administration-approved drugs and chemicals that identified the antidepressant, vilazodone, as an IPMK inhibitor. Docking simulations and pharmacophore analyses indicated that vilazodone has a greater affinity for the ATP-binding catalytic region of IPMK than ATP and we validated that vilazodone inhibits IPMK's IP ki
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