https://www.selleckchem.com/pr....oducts/Vorinostat-sa
The ORF57-driven luciferase activity had a short half-life in the presence of foscarnet. This background was then used to investigate the roles for ORF36 (thymidine kinase (TK)) and ORF13 (thymidylate synthase (TS)) in skin. The studies reveal that VZV-∆TS had increased sensitivity to brivudine and was highly impaired for skin replication. This is the first report of a phenotype that is associated with the loss of TS.Influenza A virus (IAV) is an important zoonotic pathogen, posing a severe burden for the health of both animals
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