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BACKGROUND We reported T-cell senescence to be similar in people living with HIV (PWH) with suppressed viremia (predominantly men who have sex with men (MSM)) and HIV-negative otherwise comparable controls, but greater than in healthy blood donors. This lead us to compare CD4+ and CD8+ T-cell counts and CD4+/CD8+ ratios between HIV-negative MSM and men who only have sex with women (MSW), and relate observed differences to behavioral factors and infectious exposures, including cytomegalovirus (CMV) infection. METHODS In 368 HIV-negative
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