https://www.selleckchem.com/pr....oducts/adenosine-cyc
We found that treatment of hSOD1 mice with the KCa3.1 inhibitor, TRAM-34 i) attenuates the pro-inflammatory phenotype of hypothalamic microglia; ii) increases food intake and promotes weight gain; iii) increases the number of healthy POMC (pro-opiomelanocortin) neurons; iv) changes the expression of cannabinoid receptors (CB R), involved in energy homeostasis. Using ALS mouse models, we describe defects in the hypothalamic melanocortin system that affect appetite control. These results reveal a new regulatory role for K
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