https://www.selleckchem.com/pr....oducts/Decitabine.ht
Interestingly, thrombomodulin degraded HMGB1 and consequently inhibited the induction of NETs, thereby preventing pancreatic cancer metastasis to the liver. In conclusion, NETs interact reciprocally with pancreatic cancer cells, which play a pivotal role in inflammation-associated metastasis. Targeting NETs with thrombomodulin can be a novel strategy to improve the surgical outcome of pancreatic cancer patients.The tumor microenvironment encompasses a complex cellular network that includes cancer-associated fibroblasts, inflammatory
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