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Aims To evaluate the population pharmacokinetics (PopPK) of olanzapine in children and devise a model-informed pediatric dosing scheme. Method The PopPK of olanzapine was characterized using opportunistically collected plasma samples from children receiving olanzapine per standard of care for any indication. A nonlinear mixed effect modeling approach was employed for model development using the software NONMEM (v7.4). Simulations from the developed PopPK model were used to devise a pediatric dosing scheme that targeted comparable plasma ex
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