https://www.selleckchem.com/ph....armacological_epigen
miR-511-3p directly targeted patched1 (Ptch1) and suppressed Ptch1 expression while activated the Hedgehog signaling pathway. Depletion of miR-511-3p showed a protective effect against MCT-induced HSOS, as evidenced by decreased HSOS pathogenesis factors, MMP-2, MMP-9, TNF-α and IL-1β, and decreased LSEC apoptosis rates. Nevertheless, knockdown of Ptch1 reversed the protective effect of miR-511-3p depletion against MCT-induced LSEC injury and apoptosis. miR-511-3p aggravates HSOS by activating the Hedgehog signaling pathway t
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