https://www.selleckchem.com/pr....oducts/super-tdu.htm
Objective Tofacitinib (TOF) is a Janus kinase (JAK) inhibitor used in the treatment of rheumatoid arthritis (RA), but the mechanism of its action remains unclear. In this study, we investigated the influence of TOF on gamma delta regulatory T-cell (γδTreg)/γδT17 cell balance in RA and the role of the nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome in this process. Methods We detected levels of inflammatory factors in the serum of RA patients before and after administration of TOF using an enzyme-linked imm
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