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The frameworks of synthesized substances were assigned utilizing various spectroscopic strategies such as 1H NMR, 13C NMR and HRMS. In addition, the estimation of ADME variables for several compounds had been done using in silico process. The assessment of in vitro COX-1/COX-2 enzyme inhibition had been applied in line with the fluorometric technique. According to the enzyme inhibition results, synthesized compounds showed the selectivity against COX-2 chemical inhibition as expected
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