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To evaluate the use of prospective screening for the HLA-B*5801 allele to identify Taiwanese individuals at risk of severe cutaneous adverse reactions (SCARs) induced by allopurinol treatment. National prospective cohort study. 15 medical centres in different regions of Taiwan, from July 2009 to August 2014. 2926 people who had an indication for allopurinol treatment but had not taken allopurinol previously. Participants were excluded if they had undergone a bone marrow transplant, were not of Han Chinese descent, and had a history of a
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