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In V. harveyi, numerous virulence aspects production and bioluminescence formation depend on its quorum sensing (QS) system. Consequently, the QS system is commonly investigated as a very good possible target for the treatment of V. harveyi infection. This viewpoint centers on the quorum sensing inhibitors (QSIs) of V. harveyi QS systems (LuxM/N, LuxS/PQ, and CqsA/S) and evaluates medicinal chemistry strategies.The Strategic Plan for Biodefense Research because of the U.S. Depart