https://www.selleckchem.com/pr....oducts/chir-99021-ct
also as potential food ingredients due to lack of toxicity at physiological concentrations.Background Ageing and chronic kidney disease (CKD) affect pharmacokinetic (PK) parameters. Since mechanisms are related and remain unclear, cytochrome P450 (CYP) 3A and drug transporter activities were investigated in the elderly with or without CKD and compared to healthy adults using a microdose cocktail. Methods Healthy young participants (n = 2, healthy elderly participants (n = 16) and elderly patients with CKD (n = 17) recei
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