https://www.selleckchem.com/pr....oducts/Semagacestat(
The gene expression profile indicated fibrogenic program-associated genes in male CD-1db/db . Male CD-1db/db displayed significantly lower urine AcSDKP when compared to that of BKS db/db at 24 weeks of age. The gene expression of proryl oligopeptidase, the enzyme essential for AcSDKP production from thymosin β4, was significantly lower in the CD-1 mice. Thymosin β4 levels were also lower in CD-1 mice. Conclusion These results suggest that CD-1db/db mice are a novel type 2 diabetic mouse model with progressive kidney and h
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