https://gabareceptor.com/index.....php/ultra-short-lip
Here, we regulate MTBD in a choice of high-affinity or low-affinity says by introducing a disulfide relationship to your stalk and analyze the ensuing structures by NMR and cryo-EM. Within the MT-unbound state, the affinity changes of MTBD are achieved by sliding of the stalk α-helix by a half-turn, which suggests that structural changes propagate from the ATPase-domain to MTBD. In inclusion, MT binding induces further sliding of the sta
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