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In orthodontic patients submitted to oral hygiene instruction, what is the efficacy of orthodontic toothbrush (O-T versus conventional toothbrush (C-T on plaque and gingival index reduction in randomized and non-randomized controlled clinical trials? Electronic database search was performed on PubMed, ClinicalTrials.gov, Cochrane Library and Google Scholar. Database research, study selection, data extraction and ROBINS-I and Risk of Bias Tool 2.0 analysis were conducted by two independently examiners in duplicate. Two different met
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