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Due to the ability of pro-oxidative events to initiate angiogenesis, VEGFA levels were evaluated in the premetastatic liver by immunohistochemistry, which revealed increased VEGFA expression in the central parts of the organ and diminished expression in the periphery. Taken together, these findings may support the concept of functional organ reorganization due to melanoma progression. © 2020 The Authors. International Journal of Experimental Pathology © 2020 International Journal of Experimental Pathology.AIM To investigate the characte
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