https://www.selleckchem.com/pr....oducts/bay-1895344-h
The gonadotropin-releasing hormone (GnRH) pulse is fundamental for mammalian reproduction GnRH pulse regimens are needed as therapies for infertile women as continuous GnRH treatment paradoxically inhibits gonadotropin release. Circumstantial evidence suggests that the hypothalamic arcuate KNDy neurons expressing kisspeptin (encoded by Kiss1), neurokinin B (encoded by Tac3), and dynorphin A serve as a GnRH pulse generator; however, no direct evidence is currently available. Here, we show that rescuing 20% KNDy neurons by tra
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