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elderly patients. Therefore, using MRAs to prevent delirium in clinical practice should be cautious. However, future welldefined and large sample size studies could verify these findings.Blood-Brain Barrier (BB acts as a highly impermeable barrier, presenting an impediment for the crossing of most classical drugs targeted for neurodegenerative diseases including Parkinson's disease (PD). Pertaining to the nature of drugs and other potential molecules, they impose unavoidable dose-restricted limitations eventually leading to the failu
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