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In vitro experiments were carried out using myotubes produced by C2C12 myob) occurs leading to persistent activation/overexpression of RAGE, which causes hallmarks of cancer tumors cachexia (for example. muscle tissue wasting, systemic irritation, and release of tumour-derived pro-cachectic factors). Absence of TREND in mice translates into reduced serum quantities of cachexia-inducing elements, delayed lack of muscles and energy, paid down tumour progression, a
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