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3288_3289del and c.3394G  A), 6 as likely pathogenic (c.211C  T, c.1429G  A, c.1643C  T, c.2422C  A, c.2694 + 1G  A, c.3976G  A and SMAD1 c.27delinsGTAAAG) and 3 as Variants of Uncertain Significance (c.298G  A, c.2176G  A and c.3238G  A). In all, we show that coupling in silico tools with in vitro biochemical studies can improve the classification of genetic variants.Statistical learning is a key mechanism for detecting regularities from a variety of sensory inputs. Precocial newborn domestic chic