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elp to prevent the use of e-cigarettes and combustible cigarettes. The COVID-19 pandemic has brought dramatic changes to the daily lives of U.S. adolescents, including isolation from friends and extended family, transition to remote learning, potential illness and death of loved ones, and economic distress. This study's purpose is to measure changes in adolescents' perceived stress and mood early in the pandemic. The present study drew from a racially and ethnically diverse sample of high school student participants in an ongoing interv