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788, 95% CI 1.916-17.485, = 0.002) in multivariate analysis. No significant differences were observed in the eradication rate of regimens among , and genotypes. Genotyping for *1/*22, *1/*3 and *1/*2/*3/*17 before vonoprazan-containing eradication treatment may not be useful for predicting clinical outcomes. Genotyping for CYP3A4 *1/*22, CYP3A5 *1/*3 and CYP2C19 *1/*2/*3/*17 before vonoprazan-containing eradication treatment may not be useful for predicting clinical outcomes.Nigella sativa (NS) has been used for centuries in various inflam