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To achieve optimal flexibility in biological internal fracture fixation two questions require clarification which biomechanical parameter controls healing and what are the boundary conditions thereof? Fracture movement interacts with callus and local stress and strain are influencing the reaction of the tissue cells. A linear gradient of strain was created inside a sheep tibia osteotomy using an active external fixator. The effect of different amounts of strain applied at 10 stimulation cycles/day on the occurrence of callus and on enabling
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