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Inhibition of hyper type We IFN signaling promotes cDC2 subtype development. Relb is really important to development of cDC2 subtype and here we analyzed its impact on type we IFN signaling in DCs. We reveal that Relb suppresses the homeostatic type we IFN signaling in cDC2 cultures. TLR stimulation of FL-DCs resulted in RelB induction coinciding with autumn in IFN signatures; conforming aided by the observation Relb phrase reduced TLR stimulated IFN induction along side decreas
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