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Survival in the HBOT group (57.1%) was significantly higher than that in the controls (12.5%, = 0.029), whereas IL-6, IL-10, and ALT levels were significantly lower in the HBOT group. The ROS generation was significantly inhibited to a greater extent in the HBOT group than in the control group. Additionally, in the HBOT group, the p-Akt and p-GSK-3β increased significantly and cleaved caspase-3 levels decreased significantly. HBOT showed a beneficial effect on acute liver injury and rat survival by enhancing the Akt signaling pathway an
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