https://www.selleckchem.com/pr....oducts/srt2104-gsk22
In most cases we investigated, the Hi3 + 3 design is superior than the i3 + 3 design due to information borrow from historical data. Even when the historical data is incompatible with the current data, it is capable of maintaining a high level of safety for trial patients and comparable performances without sacrificing the ability to identify the correct MTD too much. Ilustration of this feature are found in the simulation results. With the demonstrated safety, efficiency, and simplicity, the Hi3 + 3 design could be a desirab
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