https://www.selleckchem.com/pe....ptide/pki-14-22-amid
g., hypotension; these were evident during clonidine infusion. Epidurally, the antinociceptive potency of fadolmidine was weaker (ED50 128 μg) than when intrathecally administered and weaker than that of epidural clonidine (ED50 51 μg). At analgesic doses, fadolmidine injection induced moderate initial hypertension concomitantly with a decrease in heart rate whereas clonidine evoked hypotension and bradycardia. These results suggest that especially when non-opioid long-term pain relief is needed, an intrathecal infu
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