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Collectively, our outcomes suggest that the blend of DS-8201, BAY1895344, and AZD2281 exerts significant synergistic antitumor activity, suggesting that DNA damage-repair inhibitors in combination with HER2-targeted ADCs is a possible method for the treatment of HER2-positive malignancies, offering a promising technique for future clinical applications.DOT1L, really the only histone H3 lysine 79 methyltransferase, features a prominent influence on marketing the dev
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