https://www.selleckchem.com/products/SRT1720.html
In mice, both Alprolix and BeneFIX bind Col4 with similar affinities (Kd~20-40nM) and show dose-dependent recoveries. As expected, the concentration of binding sites in the mouse calculated for Alprolix (574nM) was greater than for BeneFIX (405nM), due to Alprolix binding to both Col4 and the endothelial cell neonatal Fc receptor. Preclinical and clinical results support the interpretation that FIX plays a role in haemostasis from its extravascular location. We believe that knowing the CRM status of haemophilia B patients is important f
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