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Little is known about the estrogen exposure measurement and mutual effect of age at menarche and age at menopause in the risk of cardiovascular disease (CVD) events. To evaluate estrogen exposure measurement and describe mutual effect of age at menarche and age at menopause in the risk of CVD events. Systematic review of literature in PubMed, Embase and Web of Science for studies published up to 28 June 2020. Observational studies related to estrogen exposure measurement, including mutual effect of age at menarche and age at menopause and
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