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Besides the canonical gene transfer mechanisms transformation, transduction and conjugation, DNA transfer involving extracellular vesicles is still under appreciated. However, this widespread phenomenon has been observed in the three domains of life. Here, we propose the term 'Vesiduction' as a fourth mode of intercellular DNA transfer. All known forms of life evolve mainly thanks to recombination, allowing gene duplication, gene acquisition, domain shuffling, and gene deletion. In Bacteria and Archaea, genome evolution via recombinatio
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