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54 (0.35, 0.87), (P=0.002). The preload recruitable stroke work (PRSW) increased as did PRSW indexed for Ea (both P=0.002), which reflected 'total circulatory performance'. In NIDCM, adding MRA to conventional anti-failure therapy markedly improved LV ejection fraction and reduced peripheral vascular resistance, due to both improved LV contractility and especially to enhanced V-A coupling, as Ea decreased to normal. Total circulatory performance was a sensitive indicator of both LV pump performance and the arterial loading conditions.
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