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To evaluate the different definition of refractoriness in uveitis in the literature. We systematically searched the literature in order to identify definitions of refractory noninfectious uveitis in adult patients. A search strategy in the databases of MEDLINE and Scopus was used to find articles published between January 2005 and October 2018. Definitions of corticosteroids-refractoriness were related to two main concepts persistence of inflammation despite the use of corticosteroid and recurrences above a dosage threshold. In terms of immunomodulatory the
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