https://www.selleckchem.com/pr....oducts/ldc203974-imt
Despite the introduction of direct oral anticoagulants, the search for new oral anticoagulants remains an urgent task. By using docking and scoring, based on physical methods, simple chemical rules, methods of synthesis, and activity measurement, develop new low-molecular-weight inhibitors of factor Xa, which are potential anticoagulants. The development of leads was based on chemical synthesis and structure-based drug design methods. The basic idea was to combine the two approaches one based on predictive modeling and the other
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