https://www.selleckchem.com/pr....oducts/Obatoclax-Mes
Study design In this study, we decided to change the activity of periaqueductal gray (PAG)'s metabotropic glutamate receptors subtype 8 (mGluR8) by means of its specific agonist, (S)-3,4-dicarboxyphenylglycine (DCPG), and by knock downing it with mGluR8 siRNA. We then evaluated the changes in animal pain threshold levels in the face of painful thermal stimuli (thermal hyperalgesia). Purpose Although several mechanisms have been examined for central neuropathic pain, researchers have so far failed to find the precise mechanism
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