https://www.selleckchem.com/JAK.html
There is increasing evidence of astrocyte dysfunction in the pathogenesis of Alzheimer's disease (AD). Animal studies supported by human post-mortem work have demonstrated two main astrocyte types the C3 immunopositive neurotoxic A1 astrocytes and the S100A10 immunopositive neuroprotective A2 astrocytes. A1 astrocytes predominate in AD, but the number of cases has been relatively small. We examined post-mortem brains from a larger cohort of AD cases and controls employing C3 and S100 immunohistochemistry to identify the astrocytic subtypes. There we
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