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When BCL6 phrase or activity ended up being lower in these outlines, increased apoptosis and a profound loss of proliferation ended up being seen, in keeping with gene phrase signatures suggestive of anti-apoptotic and pro-survival signaling role for BCL6 in glioblastoma. Additional, treatment utilizing the standard therapies for glioblastoma-ionizing radiation and temozolomide-both induced BCL6 phrase in vitro, and an in vivo orthotopic animal type of glioblastoma. Si
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