https://www.selleckchem.com/pr....oducts/Rapamycin.htm
In both groups, AUC values in the vitreous were significantly higher than in plasma, with plasma exposure at only approximately 11-12% of the level of vitreous exposure. The results confirmed the important role of the choroidal vessels in the pharmacokinetics of topotecan during transscleral administration and showed a positive effect of cryotherapy on intravitreal penetration, resulting in a significantly higher total exposure in the vitreous.Hypoxia-induced drug resistance (HDR) is a critical issue in cancer therapy. The presence of
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