https://www.selleckchem.com/pr....oducts/bexotegrast.h
The experiments showed that BBR inhibited SW480 cells proliferation with IC of 3.436 μM, induced apoptosis, autophage, MMP depolarization and arrested G1 phase of cell cycle at 1.0 μM. BBR dose-dependently up-regulated PTEN, while inhibited Notch1, PI3K, Akt and mTOR proteins at 1.0-9.0 μM ( 0.05). BBR also acted synergistically with Hsp90 and HDAC inhibitor (0.01 μM) in SW480 cells at 0.5 and 1.0 μM. The integrative gene expression-based chemical genomic method using CMAP analysis may be applicable for mechanistic studies of
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