https://www.selleckchem.com/pr....oducts/brincidofovir
812, p less then 0.001) indicated that nasal mucosal drug permeability is estimable from in vitro membrane permeability. Furthermore, bioavailability following IN administration significantly correlated with the in vitro Papp across Calu-3 cells (r2 = 0.984, p less then 0.001), suggesting that in vivo drug absorption following IN administration can be predicted from in vitro Calu-3 membrane permeability. We evaluated the usefulness of quality control dissolution data collected with compendial Apparatus I and II, biorelevant dissol
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