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This report would reiterate the fact that syphilis and HIV co-infection can alter the natural course of both the diseases and a high index of suspicion is required for treating them.Syphilis is known to inflict human being since long. It has varied clinical presentations. Atypical presentations are not uncommon and may jeopardize the clinical acumen of experienced clinician. Here, we are reporting a case of syphilis presenting as a sole manifestation in oral cavity.Cutaneous, mucosal, and nail examination is the key to unveiling a pletho
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